Intrauterine insemination (IUI)

Intrauterine insemination (IUI)

Intrauterine insemination (IUI) is a fertility treatment method by which sperm is placed directly into the womb, close to the time of ovulation. It’s an affordable alternative to natural conception, and it has a success rate of up to 15%.

Reasons to do IUI
IUI is often the first form of treatment for women who experience unexplained infertility. It can be helpful when there is any of these situations that can impede successful natural conceptions:

Process of IUI
IUI involves collecting semen samples from the father. Then, the healthiest sperm are selected to be surgically injected into the mother’s uterus. Here is how it works.

  1. Sperm selection: Semen sample, collected from the father or a sperm donor, is “washed” to keep only the healthiest and most active sperm. Chances of conception are maximized when the sample consists of only concentrated, high-quality sperm.
  2. Optimal ovulation: The mother prepares her body by maintaining a healthy lifestyle and diet to get a constant menstrual cycle. To help the body produce multiple eggs, the mother will be given an ovulation-inducing medication. To plan the timing of ovulation, doctors often use HCG hormone injections. 
  3. Insertion of sperm: Just after ovulation, the doctor will inject the sperm concentration into the uterus through a catheter. This procedure takes about 15 – 20 minutes. It will feel like getting a Pap smear. After the procedure, the mother will be required to lie down for a few minutes before resuming daily activities.
  4. The wait stage: Following the injection, the sperm will swim up the fallopian tube to fertilize with the waiting eggs. There may be some spotting a few days after the procedure. Wait for at least two weeks before testing with a pregnancy test kit.

There is a slight possibility of an infection or light spotting resulting from the procedure. Otherwise, the risks are relatively low. 

IUI is affordable and low risk compared to other fertility methods. Moreover, through IUI, same-sex couples or women who prefer to have a baby by themselves can use donor sperm to help them start a family.


Dr. Wanwadee Sapmee Panyakat (OB-GYN) (10 December 2021)


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